| Product Name | Kojic Acid Powder | Batch Number | GW20220630A |
| Quantity | 500kg | Manufacture Date | Jun. 30, 2022 |
| Expiry Date | Jun. 29, 2024 | Analysis Date | Jun. 30, 2022 |
| Characteristic | Specifications | Laboratory Values | Final Result |
| Melting Point | 153-158℃ | 154.3 | Pass |
| Heavy Metals | 20ppm max | Pass | Pass |
| Arsenic | 2ppm max | Pass | Pass |
| Loss on drying | 0.6% max | 0.11 | Pass |
| Residue on ignition | 0.2% max | 0.09 | Pass |
| Purity | 98.0 min | 99.5 | Pass |
| Totalmicrobial count | <100 cfu/g | Pass | Pass |
| Pathogenic bacteria | NIL | Pass | Pass |
| Instructions INCI name: Ectoin Appearance: White or off-white crystals or powder Recommended dosage: 0.1%-2% Usage: Can be added directly to aqueous phase Application: Skin care products, hair care products and color cosmetics. It brings functions of anti-stress, repairing, anti-inflammation, sooth- ing, moisturizing and anti-aging. |
Protection & Anti-stress | ||
| Improves cells anti-stress ability and resists external pressure | Protects Langerhans cell and enhances skin immunity function | Prevents damage from UV and visible light | |
| Human skin cells produce heat-shock proteins (HSPs) when exposed to external stress like sun-radiation or other physical and chemical stress factors. When the cells were stimulated by heat, the expression of HSPs increased rapidly and gradually recovers to the normal level. The higher the final expression of HSPs, the more intense the stimulation was. | Skin immune system activation mechanism | UV or visible light radiation can damage the DNA in skin cells to varying degrees, causing cancer in severe cases. |
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| In normal skin, Langerhans cell (LC) can capture antigens and selectively induce the activation and proliferation of skin resident regulatory T cells to maintain normal skin immune tolerance. UV irradiation can reduce the number and density of LC and their ability to present antigens, resulting in a weakened skin immune function. |
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| All the tested concentrations showed a highly significant level of photoprotection against UVA/visible light and visible light with a dose-response relationship. At 0.1 mM, the photoprotection levels of visible and UVA/visible irradiations correspond to 92.7% and 68.9%. |
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| The tests showed that UV irradiation damaged Langerhans cells and reduced their activity. After the treatment with Ecotin, the damage was significantly reduced. Compared to the positive control group, 1% Ecotin increased cell activity by 10.5% after 6 hours. |  |
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| The experimental results showed that the heat tolerance of cells was improved after the treatment with Ecotin. Compared with the positive control group (CTR+), the HSP72 expression was signficantly reduced. |
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